C₃₆H₄₄F₄O₂Si

Base Information

• Chemical Name: C₃₆H₄₄F₄O₂Si
• CAS No.: 256424-46-1
• Molecular Formula: C₃₆H₄₄F₄O₂Si
• Molecular Weight: 612.823
• Mol file: 256424-46-1.mol

Synonyms:C₃₆H₄₄F₄O₂Si

Chemical Property of C₃₆H₄₄F₄O₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₄₄F₄O₂Si

There total 13 articles about C₃₆H₄₄F₄O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

C36H42F4O2Si (221342-62-7) → C36H44F4O2Si (221342-63-8) + C36H44F4O2Si (256424-46-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1002/(SICI)1521-3773(19991115)38:22<3373::AID-ANIE3373>3.0.CO;2-F

Reference yield:

spiro[3.5]nonane-6,8-dione (221342-48-9) → C36H44F4O2Si (256424-46-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: isobutanol; p-TsOH / toluene / Heating

1.2: 77 percent / RedAl / toluene / 40 - 50 °C

2.1: 42 percent / TiCl₄; Ti(i-PrO)4 / CH₂Cl₂ / 2.17 h / -7 - 20 °C

3.1: SOCl₂; pyridine / 0 °C

3.2: NCS; (PhCO₂)2 / CH₂Cl₂ / 20 °C

3.3: DBU / dioxane / 96 °C

4.1: 78 percent / (1R,2S)-1-aminoindan-2-ol; BH₃; PhNEt₂ / tetrahydrofuran / 20 °C

5.1: 80 percent / NEt₃; DMAP / dimethylformamide / 70 °C

6.1: LiAlH₄ / tetrahydrofuran / 0 - 20 °C

With pyridine; titanium(IV) isopropylate; dmap; lithium aluminium tetrahydride; thionyl chloride; 2-methyl-propan-1-ol; (1R,2S)-1-Amino-2-indanol; borane; titanium tetrachloride; toluene-4-sulfonic acid; triethylamine; N,N-diethylaniline; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Etherification / 1.2: Reduction / 2.1: Cyclization / 3.1: Dehydration / 3.2: Chlorination / 3.3: Aromatisation / 4.1: Reduction / 5.1: Etherification / 6.1: Reduction;

DOI:10.1002/(SICI)1521-3773(19991115)38:22<3373::AID-ANIE3373>3.0.CO;2-F

Reference yield:

2-(trimethylsilyloxy)-3-methyl-1-butene (17510-45-1) → C36H44F4O2Si (256424-46-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: TiCl₄; Ti(OiPr)4 / CH₂Cl₂

1.2: 65 percent / CH₂Cl₂

2.1: SOCl₂; pyridine

2.2: NCS; (PhCO₂)2 / CH₂Cl₂

2.3: DBU; air / dioxane

3.1: BH₃*Et₂NPh; (1R,2S)-1-aminoindanol

4.1: dimethylformamide

5.1: LAH / tetrahydrofuran

With pyridine; titanium(IV) isopropylate; lithium aluminium tetrahydride; borane N,N-diethylaniline complex; thionyl chloride; (1R,2S)-1-Amino-2-indanol; titanium tetrachloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Mukaiyama-Michael addition / 1.2: Michael addition;

DOI:10.2533/000942904777678082

upstream raw materials:

C₃₆H₄₂F₄O₂Si

2-(trimethylsilyloxy)-3-methyl-1-butene

spiro[3.5]non-7-en-6-one

1-(4-fluorophenyl)-3-(4-trifluoromethylphenyl)-propen-3-one

Downstream raw materials:

C₃₆H₄₃F₅OSi