(R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

Base Information

Chemical Name:(R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene
CAS No.:1298066-12-2
Molecular Formula:C₂₈H₃₂FN₅O₄S
Molecular Weight:553.658
Hs Code.:

Synonyms:(R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

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Chemical Property of (R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

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Technology Process of (R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

There total 3 articles about (R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361345-28-9
[(R)-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalen-4a-yl]methanol

: 75-03-6
ethyl iodide

: 1298066-12-2
(R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 - 50 ℃; for 1h;

Reference yield:

: 6-(morpholin-4-yl)pyridine-3-sulfonyl chloride

: 1298066-12-2
(R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 20 °C

1.2: 1 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 1 h / 20 - 50 °C

With hydrogenchloride; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene;

Reference yield:

: 1361345-27-8
(R)-1-(4-fluorophenyl)-6-(6-morpholin-4-ylpyridine-3-sulfonyl)-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalen-4a-carboxylic acid methyl ester

: 1298066-12-2
(R)-4a-ethoxymethyl-1-(4-fluorophenyl)-6-[[6-(4-morpholinyl)-3-pyridinyl]sulfonyl]-1,4,7,8-tetrahydro-1,2,6-triazacyclopenta[b]naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 1 h / 20 - 50 °C

With sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; toluene;