1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide

Base Information

Chemical Name:1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide
CAS No.:894809-31-5
Molecular Formula:C₃₈H₄₇N₃O₃SSi
Molecular Weight:653.961
Hs Code.:

Synonyms:1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide

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Chemical Property of 1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide

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Technology Process of 1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide

There total 4 articles about 1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 203922-97-8
(1S,2S)-2-amino-1,2-diphenyl-1-ethoxycarbonylaminoethane

: 894809-30-4
(1R,2S)-1-t-butyldimethylsilyloxy-1,2-diphenyl-2-isothiocyanatoethane

: 894809-31-5
1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide

Guidance literature:: In dichloromethane; at 20 ℃; for 65h;
DOI:10.1002/adsc.200505161

Reference yield:

: 23190-16-1
(1R,2S)-2-Amino-1,2-diphenylethanol

: 894809-31-5
1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N; 4-dimethylaminopyridine / CHCl₃ / 20 - 40 °C

2: 82 percent / Et₃N; 2-chloro-1,3-dimethylimidazolium chloride / CH₂Cl₂ / 1 h / 20 °C

3: 94 percent / CH₂Cl₂ / 65 h / 20 °C

With dmap; 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine; In dichloromethane; chloroform;
DOI:10.1002/adsc.200505161

Reference yield:

: 178151-42-3
(1S,2R)-1,2-diphenyl-2-<(1,1-dimethylethyl)dimethylsiloxy>ethylamine

: 894809-31-5
1-[(1R,2S)-(2-t-butyldimethylsilyloxy-1,2-diphenylethyl)]-2-[(1S,2S)-(1,2-diphenylethyl-2-ethoxycarbonylamino)]thioamide

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Et₃N; 2-chloro-1,3-dimethylimidazolium chloride / CH₂Cl₂ / 1 h / 20 °C

2: 94 percent / CH₂Cl₂ / 65 h / 20 °C

With 2-chloro-1,3-dimethyl imidazolium chloride; triethylamine; In dichloromethane;
DOI:10.1002/adsc.200505161