tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate
CAS No.:952709-09-0
Molecular Formula:C₃₉H₆₀FN₃O₆Si
Molecular Weight:714.006
Hs Code.:

tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate

Synonyms:tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate

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Chemical Property of tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate

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Technology Process of tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate

There total 6 articles about tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 952593-53-2
(2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine hydrochloride

: 267234-20-8
(3R,4S)-3-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)pyrrolidine

: 952709-09-0
tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate

Guidance literature:: (2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine hydrochloride; bis(trichloromethyl) carbonate; With pyridine; In dichloromethane; at -78 - 20 ℃; for 1.16667h;

(3R,4S)-3-(tert-butoxycarbonylamino)-4-(tert-butyldimethylsilyloxy)pyrrolidine; With triethylamine; In dichloromethane; for 0.5h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 952709-09-0
tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2.1: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Cooling with acetone-dry ice

3.1: water; triphenylphosphine / tetrahydrofuran / 1 h / Heating / reflux

4.1: dichloromethane / 20 h / 20 °C

5.1: hydrogen / 10 % Pd(OH)2/C / methanol / 3 h / 2625.26 Torr

6.1: pyridine / dichloromethane / 1.17 h / -78 - 20 °C

6.2: 0.5 h

With pyridine; 1H-imidazole; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; water; hydrogen; triphenylphosphine; 10 % Pd(OH)2/C; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 201601-50-5
(3S,4S)-1-benzyl-3-(tert-butyldimethylsilyl)oxy-4-hydroxypyrrolidine

: 952709-09-0
tert-butyl (3R,4S)-4-(tert-butyldimethylsilyloxy)-1-((2S)-2-(1-(6-fluoro-3'-methylbiphenyl-2-yl)-5-methoxypentyl)morpholine-4-carbonyl)pyrrolidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; triphenylphosphine / tetrahydrofuran / 0 - 20 °C / Cooling with acetone-dry ice

2.1: water; triphenylphosphine / tetrahydrofuran / 1 h / Heating / reflux

3.1: dichloromethane / 20 h / 20 °C

4.1: hydrogen / 10 % Pd(OH)2/C / methanol / 3 h / 2625.26 Torr

5.1: pyridine / dichloromethane / 1.17 h / -78 - 20 °C

5.2: 0.5 h

With pyridine; di-isopropyl azodicarboxylate; diphenyl phosphoryl azide; water; hydrogen; triphenylphosphine; 10 % Pd(OH)2/C; In tetrahydrofuran; methanol; dichloromethane;