2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide

Base Information

Chemical Name:2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide
CAS No.:177558-32-6
Molecular Formula:C₃₁H₃₄N₂O₄
Molecular Weight:498.622
Hs Code.:

Synonyms:2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide

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Chemical Property of 2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide

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Technology Process of 2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide

There total 9 articles about 2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.4%

: 177559-81-8
2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

: 177558-32-6
2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide

Guidance literature:: With aluminium trichloride; borane; tert-butylamine; In toluene; at 60 ℃; for 2h;
DOI:10.1021/jm960395q

Reference yield:

: 24103-75-1
4-methoxy-2-methylpyridine

: 177558-32-6
2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 9 steps

1: ethyl acetate / 0.5 h / 70 °C

2: 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

3: 90.2 percent / benzene / 4 h / Heating

4: 39.2 percent / BH₃, t-BuNH₂, AlCl₃ / CH₂Cl₂ / 5 h

5: tetrahydrofuran / 1 h / 0 °C

6: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

7: 36.9 percent / BBr₃ / CH₂Cl₂

8: 70.9 percent / NaH / dimethylformamide / Ambient temperature

9: 79.4 percent / BH₃, t-BuNH₂, AlCl₃ / toluene / 2 h / 60 °C

With ammonium hydroxide; aluminium trichloride; borane; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm960395q

Reference yield:

: 182116-41-2
2-ethyl-7-methoxyindolizine

: 177558-32-6
2-(7-(3-Carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 90.2 percent / benzene / 4 h / Heating

2: 39.2 percent / BH₃, t-BuNH₂, AlCl₃ / CH₂Cl₂ / 5 h

3: tetrahydrofuran / 1 h / 0 °C

4: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

5: 36.9 percent / BBr₃ / CH₂Cl₂

6: 70.9 percent / NaH / dimethylformamide / Ambient temperature

7: 79.4 percent / BH₃, t-BuNH₂, AlCl₃ / toluene / 2 h / 60 °C

With ammonium hydroxide; aluminium trichloride; borane; boron tribromide; sodium hydride; tert-butylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
DOI:10.1021/jm960395q