2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Base Information

Chemical Name:2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide
CAS No.:177559-81-8
Molecular Formula:C₃₁H₃₂N₂O₅
Molecular Weight:512.605
Hs Code.:

Synonyms:2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

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Chemical Property of 2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

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Technology Process of 2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

There total 9 articles about 2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 177559-81-8
2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Guidance literature:

Reference yield: 70.9%

: 2969-81-5
Ethyl 4-bromobutyrate

: 177559-77-2
2-(2-ethyl-7-hydroxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

: 177559-81-8
2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature;
DOI:10.1021/jm960395q

Reference yield:

: 24103-75-1
4-methoxy-2-methylpyridine

: 177559-81-8
2-(7-(3-carbethoxypropyloxy)-2-ethyl-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Guidance literature:: Multi-step reaction with 8 steps

1: ethyl acetate / 0.5 h / 70 °C

2: 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

3: 90.2 percent / benzene / 4 h / Heating

4: 39.2 percent / BH₃, t-BuNH₂, AlCl₃ / CH₂Cl₂ / 5 h

5: tetrahydrofuran / 1 h / 0 °C

6: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

7: 36.9 percent / BBr₃ / CH₂Cl₂

8: 70.9 percent / NaH / dimethylformamide / Ambient temperature

With ammonium hydroxide; aluminium trichloride; borane; boron tribromide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm960395q