Technology Process of N4-Succinoyl-N1,N8-bis(N-methyl-N-(benzyloxy)succinamoyl)spermidine
There total 7 articles about N4-Succinoyl-N1,N8-bis(N-methyl-N-(benzyloxy)succinamoyl)spermidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: DMAP / CH2Cl2 / 16 h
2: 1.) HBr/HOAc (33percent), 2.) NaHCO3 / 1.) 4 h, room temperature, 2.) H2O, ethyl acetate, 24 h, room temperature
With
dmap; hydrogen bromide; sodium hydrogencarbonate; acetic acid;
In
dichloromethane;
DOI:10.1021/jm00122a013
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 98 percent / K2CO3 / H2O; ethyl acetate / Heating
2: 10.5 g / K2CO3 / acetone / 12 h / Heating
3: 93 percent / 33percent HBr/HOAc / 4 h / Ambient temperature
4: 87 percent / tetrahydrofuran / 8 h / Heating
5: 97 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0-5 deg C, 3 h, 2.) room temperature, 15 h
6: 1.) H2, 2.) aq. NaHCO3 / 1.) 10percent Pd-C / 1.) EtOH, HOAc, 2 h, 2.) ethyl acetate, 24 h, room temperature
With
hydrogen bromide; hydrogen; sodium hydrogencarbonate; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran; water; ethyl acetate; acetone;
DOI:10.1021/jm00122a013
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 87 percent / tetrahydrofuran / 8 h / Heating
2: 97 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0-5 deg C, 3 h, 2.) room temperature, 15 h
3: 1.) H2, 2.) aq. NaHCO3 / 1.) 10percent Pd-C / 1.) EtOH, HOAc, 2 h, 2.) ethyl acetate, 24 h, room temperature
With
hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
tetrahydrofuran;
DOI:10.1021/jm00122a013
