N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea

Base Information

Chemical Name:N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea
CAS No.:1621400-96-1
Molecular Formula:C₂₅H₂₈N₂O₃
Molecular Weight:404.509
Hs Code.:

Synonyms:N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea

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Chemical Property of N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea

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Technology Process of N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea

There total 3 articles about N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 119-61-9
benzophenone

: 1592614-01-1
N'-[2-(4-methoxyphenyl)ethyl]-N,N-dimethylurea

: 1621400-96-1
N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea

: 1621400-97-2
N'-{2-[2-(hydroxydiphenylmethyl)-4-methoxyphenyl]ethyl}-N,N-dimethylurea

Guidance literature:: N'-[2-(4-methoxyphenyl)ethyl]-N,N-dimethylurea; With n-butyllithium; In tetrahydrofuran; hexane; at -20 - 0 ℃; for 2h; Inert atmosphere;

benzophenone; In tetrahydrofuran; hexane; at -60 - 20 ℃; for 2h; Temperature; Time; Reagent/catalyst;
DOI:10.1055/s-0033-1338570

Reference yield:

: 104-47-2
p-methoxybenzylnitrile

: 1621400-96-1
N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea

: 1621400-97-2
N'-{2-[2-(hydroxydiphenylmethyl)-4-methoxyphenyl]ethyl}-N,N-dimethylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride; aluminum (III) chloride / diethyl ether / 0 - 20 °C

2.1: triethylamine / dichloromethane / 1 h / Reflux

3.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere

3.2: 2 h / -60 - 20 °C

With aluminum (III) chloride; lithium aluminium tetrahydride; n-butyllithium; triethylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1055/s-0033-1338570

Reference yield:

: 55-81-2
4-Methoxyphenethylamine

: 1621400-96-1
N-(2-hydroxy-2,2-diphenylethyl)-N′-[2-(4-methoxyphenyl)ethyl]-N-methylurea

: 1621400-97-2
N'-{2-[2-(hydroxydiphenylmethyl)-4-methoxyphenyl]ethyl}-N,N-dimethylurea

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 1 h / Reflux

2.1: n-butyllithium / hexane; tetrahydrofuran / 2 h / -20 - 0 °C / Inert atmosphere

2.2: 2 h / -60 - 20 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1055/s-0033-1338570