(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

Base Information

Chemical Name:(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone
CAS No.:1362020-39-0
Molecular Formula:C₂₀H₁₈Cl₂N₆O₃
Molecular Weight:461.307
Hs Code.:

Synonyms:(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

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Chemical Property of (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

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Technology Process of (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

There total 4 articles about (4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.9%

: 1362020-73-2
C₁₀H₈ClN₃O₂

: 114878-60-3
1-(2-chloro-4-nitro-phenyl)piperazine

: 1362020-39-0
(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

Guidance literature:: C₁₀H₈ClN₃O₂; With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

1-(2-chloro-4-nitro-phenyl)piperazine; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 3h; Cooling with ice;
DOI:10.1021/jm2013503

Reference yield:

: 3296-05-7
1-azido-4-chlorobenzene

: 1362020-39-0
(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 120 °C

2.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 3 h / 20 °C / Cooling with ice

With oxalyl dichloride; water; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm2013503

Reference yield:

: 1362020-59-4
C₁₂H₁₂ClN₃O₂

: 1362020-39-0
(4-(2-chloro-4-nitrophenyl)piperazin-1-yl)(1-(4-chlorophenyl)-4-methyl-1H-1,2,3-triazol-5-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran; methanol / 20 °C

2.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 20 °C

2.2: 3 h / 20 °C / Cooling with ice

With oxalyl dichloride; water; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2013503