[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate

Base Information

Chemical Name:[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate
CAS No.:1429872-88-7
Molecular Formula:C₂₀H₁₇F₃N₂O₆S₂
Molecular Weight:502.492
Hs Code.:

Synonyms:[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate

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Chemical Property of [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate

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Technology Process of [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate

There total 6 articles about [2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1429870-80-3
4-hydroxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

: 98-59-9
p-toluenesulfonyl chloride

: 1429872-88-7
[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate

Guidance literature:: With potassium carbonate; In acetonitrile; at 20 ℃;

Reference yield:

: 1429874-17-8
4-methoxy-2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]pyridazin-3-one

: 1429872-88-7
[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: morpholine / 3 h / 100 °C

2: potassium carbonate / acetonitrile / 20 °C

With morpholine; potassium carbonate; In acetonitrile;

Reference yield:

: 933-76-6
4,5-dichloro-2-methyl-3(2H)-pyridazinone

: 1429872-88-7
[2-methyl-5-[2-methylsulfonyl-4-(trifluoromethyl)phenyl]-3-oxo-pyridazin-4-yl] 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 1,4-dioxane / 1 h / 20 °C

2: tricyclohexylphosphine; potassium acetate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.25 h / 150 °C / Microwave irradiation

3: cesium fluoride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 160 °C / Microwave irradiation

4: dihydrogen peroxide; acetic acid / water / 55 °C

5: morpholine / 3 h / 100 °C

6: potassium carbonate / acetonitrile / 20 °C

With morpholine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; dihydrogen peroxide; potassium acetate; potassium carbonate; acetic acid; cesium fluoride; tricyclohexylphosphine; In 1,4-dioxane; 1,2-dimethoxyethane; water; acetonitrile;