methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate

Base Information

Chemical Name:methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate
CAS No.:1609575-86-1
Molecular Formula:C₁₉H₁₈FNO₆
Molecular Weight:375.353
Hs Code.:

Synonyms:methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate

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Chemical Property of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate

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Technology Process of methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate

There total 3 articles about methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 622-33-3
N-benzyloxyamine

: 583880-89-1
methyl 4-fluoro-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoate

: 1609575-86-1
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate

Guidance literature:: In toluene; Reflux; Dean-Stark;
DOI:10.1021/jm500109z

Reference yield:

: 1006-41-3
2-bromo-4-fluorobenzoic acid

: 1609575-86-1
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) bromide; sodium hydride / mineral oil; toluene / 2.5 h / 75 °C / Inert atmosphere

2: thionyl chloride / 16 h / 0 °C / Reflux

3: toluene / Reflux; Dean-Stark

With thionyl chloride; sodium hydride; copper(I) bromide; In toluene; mineral oil;
DOI:10.1021/jm500109z

Reference yield:

: 141829-04-1
4-fluoro-2-(1,3-dimethoxy-1,3-dioxopropan-2-yl)benzoic acid

: 1609575-86-1
methyl 2-{1-[(benzyloxy)amino]-3-methoxy-1,3-dioxopropan-2-yl}-4-fluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 16 h / 0 °C / Reflux

2: toluene / Reflux; Dean-Stark

With thionyl chloride; In toluene;
DOI:10.1021/jm500109z