1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol

Base Information

Chemical Name:1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol
CAS No.:1613505-28-4
Molecular Formula:C₁₉H₁₇F₃N₂O₂
Molecular Weight:362.351
Hs Code.:

Synonyms:1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol

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Chemical Property of 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol

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Technology Process of 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol

There total 7 articles about 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1613504-91-8
C₂₀H₁₉F₃N₂O₂

: 1613505-28-4
1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol

Guidance literature:: With sodium hydroxide; 1-dodecylthiol; In 1-methyl-pyrrolidin-2-one; at 130 ℃; for 21h;

Reference yield:

: 152626-77-2
4-bromo-5-methoxy-2-methylaniline

: 1613505-28-4
1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / -78 - 20 °C / Inert atmosphere

2: potassium acetate; 18-crown-6 ether / dichloromethane / 1 h / 20 °C

3: toluene-4-sulfonic acid / chloroform / 20 - 50 °C

4: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Microwave irradiation

5: 1-dodecylthiol; sodium hydroxide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Sealed tube; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; potassium acetate; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; 1-dodecylthiol; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform; water; 4: |Suzuki Coupling;
DOI:10.1021/jm401986p

Reference yield:

: 1613504-83-8
5-bromo-6-methoxy-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

: 1613505-28-4
1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Microwave irradiation

2: 1-dodecylthiol; sodium hydroxide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Sealed tube; Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; caesium carbonate; sodium hydroxide; 1-dodecylthiol; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; 1: |Suzuki Coupling;
DOI:10.1021/jm401986p