1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate

Base Information

Chemical Name:1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate
CAS No.:1613505-29-5
Molecular Formula:C₂₀H₁₆F₆N₂O₄S
Molecular Weight:494.414
Hs Code.:

Synonyms:1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate

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Chemical Property of 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate

There total 6 articles about 1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1613505-28-4
1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-ol

: 1613505-29-5
1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 120 ℃; for 0.4h; Microwave irradiation;
DOI:10.1021/jm401986p

Reference yield:

: 1613504-76-9
4-bromo-5-methoxy-2-methylbenzenediazonium tetrafluoroborate

: 1613505-29-5
1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: potassium acetate; 18-crown-6 ether / dichloromethane / 1 h / 20 °C

2: toluene-4-sulfonic acid / chloroform / 20 - 50 °C

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Microwave irradiation

4: 1-dodecylthiol; sodium hydroxide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Sealed tube; Inert atmosphere

5: potassium carbonate / tetrahydrofuran / 0.4 h / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; potassium acetate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; 1-dodecylthiol; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform; water; 3: |Suzuki Coupling;
DOI:10.1021/jm401986p

Reference yield:

: 152626-77-2
4-bromo-5-methoxy-2-methylaniline

: 1613505-29-5
1-(tetrahydro-2H-pyran-2-yl)-5-(2-(trifluoromethyl)phenyl)-1H-indazol-6-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: dichloromethane / -78 - 20 °C / Inert atmosphere

2: potassium acetate; 18-crown-6 ether / dichloromethane / 1 h / 20 °C

3: toluene-4-sulfonic acid / chloroform / 20 - 50 °C

4: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 120 °C / Microwave irradiation

5: 1-dodecylthiol; sodium hydroxide / 1-methyl-pyrrolidin-2-one / 5 h / 130 °C / Sealed tube; Inert atmosphere

6: potassium carbonate / tetrahydrofuran / 0.4 h / 120 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 18-crown-6 ether; potassium acetate; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; sodium hydroxide; 1-dodecylthiol; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; chloroform; water; 4: |Suzuki Coupling;
DOI:10.1021/jm401986p