(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester

Base Information

Chemical Name:(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester
CAS No.:180712-50-9
Molecular Formula:C₂₅H₂₉NO₉S
Molecular Weight:519.573
Hs Code.:

Synonyms:(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester

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Chemical Property of (2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester

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Technology Process of (2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester

There total 8 articles about (2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 180712-46-3
(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester

: 180712-50-9
(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester

Guidance literature:: With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triphenylphosphine; In dichloromethane; at -15 ℃; for 0.5h;
DOI:10.1016/0040-4020(96)00765-X

Reference yield:

: 7314-44-5
2,4-dimethoxylbenzyl alcohol

: 180712-50-9
(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0.08 h / 0 °C

2: CH₂Cl₂; acetone / 18 h / Ambient temperature

3: 1.) lithium bis(trimethylsilylamide) / 1.) THF, hexane, from -78 deg C to -30 deg C, 2 h, 2.) THF, hexane, -78 deg C, 1 h

4: 100 percent / Pd(PPh₃)4, PPh₃, pyrrolidine / CH₂Cl₂ / 0.5 h / -15 °C

With pyrrolidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; In dichloromethane; acetone;
DOI:10.1016/0040-4020(96)00765-X

Reference yield:

: 141996-68-1
alloc-L-aspartic acid

: 180712-50-9
(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 4-(4-methoxy-benzyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / acetic anhydride / tetrahydrofuran / 5 h / 50 - 60 °C

2: 52 percent / 72 h / Ambient temperature

3: 87 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / CH₂Cl₂ / 48 h / Ambient temperature

4: 1.) lithium bis(trimethylsilylamide) / 1.) THF, hexane, from -78 deg C to -30 deg C, 2 h, 2.) THF, hexane, -78 deg C, 1 h

5: 100 percent / Pd(PPh₃)4, PPh₃, pyrrolidine / CH₂Cl₂ / 0.5 h / -15 °C

With pyrrolidine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic anhydride; dicyclohexyl-carbodiimide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0040-4020(96)00765-X