(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester

Base Information

Chemical Name:(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester
CAS No.:180712-46-3
Molecular Formula:C₂₈H₃₃NO₉S
Molecular Weight:559.637
Hs Code.:

Synonyms:(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester

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Chemical Property of (2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester

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Technology Process of (2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester

There total 6 articles about (2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7314-44-5
2,4-dimethoxylbenzyl alcohol

: 180712-46-3
(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 0.08 h / 0 °C

2: CH₂Cl₂; acetone / 18 h / Ambient temperature

3: 1.) lithium bis(trimethylsilylamide) / 1.) THF, hexane, from -78 deg C to -30 deg C, 2 h, 2.) THF, hexane, -78 deg C, 1 h

With triethylamine; lithium hexamethyldisilazane; In dichloromethane; acetone;
DOI:10.1016/0040-4020(96)00765-X

Reference yield:

: 141996-68-1
alloc-L-aspartic acid

: 180712-46-3
(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / acetic anhydride / tetrahydrofuran / 5 h / 50 - 60 °C

2: 52 percent / 72 h / Ambient temperature

3: 87 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / CH₂Cl₂ / 48 h / Ambient temperature

4: 1.) lithium bis(trimethylsilylamide) / 1.) THF, hexane, from -78 deg C to -30 deg C, 2 h, 2.) THF, hexane, -78 deg C, 1 h

With dmap; acetic anhydride; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0040-4020(96)00765-X

Reference yield:

: 180712-37-2
N-allyloxycarbonyl-L-aspartic anhydride

: 180712-46-3
(2R,3R)-2-Allyloxycarbonylamino-3-(2,4-dimethoxy-benzylsulfanyl)-succinic acid 1-allyl ester 4-(4-methoxy-benzyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / 72 h / Ambient temperature

2: 87 percent / dicyclohexylcarbodiimide, 4-N,N-dimethylaminopyridine / CH₂Cl₂ / 48 h / Ambient temperature

3: 1.) lithium bis(trimethylsilylamide) / 1.) THF, hexane, from -78 deg C to -30 deg C, 2 h, 2.) THF, hexane, -78 deg C, 1 h

With dmap; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In dichloromethane;
DOI:10.1016/0040-4020(96)00765-X