(E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester

Base Information

• Chemical Name: (E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester
• CAS No.: 220631-39-0
• Molecular Formula: C₁₂H₁₃ClO₃
• Molecular Weight: 240.686
• Mol file: 220631-39-0.mol

Synonyms:(E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester

Chemical Property of (E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester

There total 1 articles about (E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + (E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoyl chloride → (E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester (220631-39-0)

Guidance literature:

for 2h; Yield given;

DOI:10.1039/a807005i

Reference yield: 75.0%

(E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester (220631-39-0) → (4S,5S)-5-(2-Chloro-5-methoxy-phenyl)-4-hydroxy-dihydro-furan-2-one

Guidance literature:

With osmium(VIII) oxide; N-methyl-2-indolinone; water; In acetone; 1.) 0 deg C to r.t., 2.) r.t., 18 h;

DOI:10.1039/a807005i

Reference yield:

(E)-4-(2-Chloro-5-methoxy-phenyl)-but-3-enoic acid methyl ester (220631-39-0) → (3S,4S)-4-(2-Chloro-5-methoxy-phenyl)-3,4-dihydroxy-butyric acid methyl ester

Guidance literature:

Multi-step reaction with 3 steps

1: 75 percent / NMO, OsO₄, H₂O / acetone / 1.) 0 deg C to r.t., 2.) r.t., 18 h

2: 81 percent / (+/-)-camphorsulfonic acid / CH₂Cl₂ / 72 h / Heating

3: 12 percent / TiCl₄ / CH₂Cl₂ / 5 h / Ambient temperature

With osmium(VIII) oxide; N-methyl-2-indolinone; camphor-10-sulfonic acid; water; titanium tetrachloride; In dichloromethane; acetone;

DOI:10.1039/a807005i

upstream raw materials:

methanol