2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene

Base Information

Chemical Name:2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene
CAS No.:220728-68-7
Molecular Formula:C₂₂H₂₈O₃S
Molecular Weight:372.529
Hs Code.:

Synonyms:2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene

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Chemical Property of 2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene

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Technology Process of 2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene

There total 12 articles about 2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 870-63-3
prenyl bromide

: 220728-49-4
(S)-2-methoxy-1-methyl-4-(1-(phenylsulfonyl)propan-2-yl)benzene

: 220728-68-7
2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene

Guidance literature:: (S)-2-methoxy-1-methyl-4-(1-(phenylsulfonyl)propan-2-yl)benzene; With n-butyllithium; In tetrahydrofuran; hexane; at -50 ℃; for 0.5h; Inert atmosphere;

prenyl bromide; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; hexane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tetasy.2014.10.016

Reference yield:

: 220728-62-1
4-iodo-2-methoxy-1-methylbenzene

: 220728-68-7
2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 75 percent / Ph₃P; iPr₂NEt / Pd(OAc)2 / dimethylformamide / 80 °C

2.1: O₃ / CH₂Cl₂; methanol / -78 °C

2.2: 63 percent / NaBH₄ / 20 °C

3.1: PPL / diethyl ether / 39 °C

4.1: Et₃N; 4-DMAP / CH₂Cl₂ / 20 °C

4.2: 65 percent / NaBH₄ / dimethylsulfoxide / 60 °C

5.1: 84 percent / nBu₃P / pyridine / 20 °C

6.1: 100 percent / MCPBA; KHCO₃ / CH₂Cl₂ / 20 °C

7.1: 82 percent / nBuLi; HMPA / tetrahydrofuran / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; tributylphosphine; potassium hydrogencarbonate; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium diacetate; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1.1: Arylation / 2.1: Ozonolysis / 2.2: Reduction / 3.1: Acetylation / 4.1: Tosylation / 4.2: Reduction / 5.1: Substitution / 6.1: Oxidation / 7.1: Alkylation;
DOI:10.3987/com-98-s(h)4

Reference yield:

: 220728-63-2
2-tert-butyl-5-(3-methoxy-4-methyl-phenyl)-4,5-dihydro-[1,3]dioxepine

: 220728-68-7
2-methoxy-1-methyl-4-((2S)-6-methyl-3-(phenylsulfonyl)hept-5-en-2-yl)benzene

Guidance literature:: Multi-step reaction with 6 steps

1.1: O₃ / CH₂Cl₂; methanol / -78 °C

1.2: 63 percent / NaBH₄ / 20 °C

2.1: PPL / diethyl ether / 39 °C

3.1: Et₃N; 4-DMAP / CH₂Cl₂ / 20 °C

3.2: 65 percent / NaBH₄ / dimethylsulfoxide / 60 °C

4.1: 84 percent / nBu₃P / pyridine / 20 °C

5.1: 100 percent / MCPBA; KHCO₃ / CH₂Cl₂ / 20 °C

6.1: 82 percent / nBuLi; HMPA / tetrahydrofuran / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; n-butyllithium; tributylphosphine; potassium hydrogencarbonate; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid; PPL; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; 1.1: Ozonolysis / 1.2: Reduction / 2.1: Acetylation / 3.1: Tosylation / 3.2: Reduction / 4.1: Substitution / 5.1: Oxidation / 6.1: Alkylation;
DOI:10.3987/com-98-s(h)4