7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride

Base Information

Chemical Name:7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride
CAS No.:1354721-17-7
Molecular Formula:C₂₈H₂₉N₃O₃*ClH
Molecular Weight:492.017
Hs Code.:

Synonyms:7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride

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Chemical Property of 7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride

Chemical Property:

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Technology Process of 7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride

There total 5 articles about 7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354721-16-6
7-[3-(1-tert-butoxycarbonyl-pyrrolidin-2-yl)-benzoylamino]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester

: 1354721-17-7
7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 24h;

Reference yield:

: 99365-69-2
7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride

: 1354721-17-7
7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / ethyl acetate; water / 24 h / 0 - 20 °C

2.1: hydrogenchloride; tin(ll) chloride; acetic acid; tin(II) chloride dihdyrate / water / 48 h / 20 °C

2.2: 1.08 h / pH 5 - 10 / Cooling with ice

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 24 h / 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tin(ll) chloride; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 1354721-17-7
7-(3-pyrrolidin-2-ylbenzoylamino)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / ethyl acetate; water / 24 h / 0 - 20 °C

2.1: hydrogenchloride; tin(ll) chloride; acetic acid; tin(II) chloride dihdyrate / water / 48 h / 20 °C

2.2: 1.08 h / pH 5 - 10 / Cooling with ice

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 24 h / 65 °C

4.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 24 h / 20 °C

With hydrogenchloride; tin(II) chloride dihdyrate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tin(ll) chloride; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;