[3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester

Base Information

• Chemical Name: [3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester
• CAS No.: 872315-76-9
• Molecular Formula: C₄₁H₄₇N₅O₁₀
• Molecular Weight: 769.852

Synonyms:[3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester

Chemical Property of [3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester

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Technology Process of [3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester

There total 3 articles about [3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(3-aminopropyl)carbamic acid benzyl ester hydrochloride (17400-34-9) + 1-{(3aR,4R,6R,6aR)-6-[(2S,3R)-3-(2,3-Dihydro-indole-1-carbonyl)-oxiranyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-3-(4-methoxy-benzyl)-1H-pyrimidine-2,4-dione (616894-52-1) → [3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester (872315-76-9)

Guidance literature:

(3-aminopropyl)carbamic acid benzyl ester hydrochloride; With triethylamine; In methanol; at 20 ℃; for 0.5h;

1-{(3aR,4R,6R,6aR)-6-[(2S,3R)-3-(2,3-Dihydro-indole-1-carbonyl)-oxiranyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-3-(4-methoxy-benzyl)-1H-pyrimidine-2,4-dione; In methanol; for 96h; Heating;

DOI:10.1016/j.tet.2005.09.086

Reference yield:

(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde (121845-98-5) → [3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester (872315-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 78 percent / aq. NaOH / CH₂Cl₂ / 2.5 h / 0 °C

2.1: Et₃N / methanol / 0.5 h / 20 °C

2.2: 83 percent / methanol / 96 h / Heating

With sodium hydroxide; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.tet.2005.09.086

Reference yield:

C12H16NOS(1+)*BF4(1-) → [3-((1S,2R)-1-(2,3-Dihydro-indole-1-carbonyl)-2-hydroxy-2-{(3aR,4R,6R,6aR)-6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propyl]-carbamic acid benzyl ester (872315-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 78 percent / aq. NaOH / CH₂Cl₂ / 2.5 h / 0 °C

2.1: Et₃N / methanol / 0.5 h / 20 °C

2.2: 83 percent / methanol / 96 h / Heating

With sodium hydroxide; triethylamine; In methanol; dichloromethane;

DOI:10.1016/j.tet.2005.09.086

upstream raw materials:

(3-aminopropyl)carbamic acid benzyl ester hydrochloride

1-{(3aR,4R,6R,6aR)-6-[(2S,3R)-3-(2,3-Dihydro-indole-1-carbonyl)-oxiranyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-3-(4-methoxy-benzyl)-1H-pyrimidine-2,4-dione

(3aR,4S,6R,6aS)-6-(3-(4-methoxybenzyl)-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-tetrahydro-2,2-dimethylfuro[3,4-d][1,3]dioxole-4-carbaldehyde

Downstream raw materials:

{1-[3-(1-(2,3-dihydro-indole-1-carbonyl)-2-hydroxy-2-{6-[3-(4-methoxy-benzyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-ethylamino)-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

1-{(3aR,4R,6R,6aR)-6-[(1R,2S)-2-(3-Amino-propylamino)-3-(2,3-dihydro-indol-1-yl)-1-hydroxy-3-oxo-propyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-3-(4-methoxy-benzyl)-1H-pyrimidine-2,4-dione

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