tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

Base Information

Chemical Name:tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate
CAS No.:1313440-74-2
Molecular Formula:C₃₀H₃₁N₃O₄
Molecular Weight:497.594
Hs Code.:

Synonyms:tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

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Chemical Property of tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

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Technology Process of tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

There total 1 articles about tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1313440-28-6
tert-butyl 1-(4-(5-amino-6-oxo-3-phenyl-1,6-dihydropyridin-2-yl)phenyl)cyclobutylcarbamate

: 82820-87-9
2,4-dibromobutanoyl chloride

: 1313440-74-2
tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

: 1313440-73-1
tert-butyl 1-(4-(3-(2-hydroxyethyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: tert-butyl 1-(4-(5-amino-6-oxo-3-phenyl-1,6-dihydropyridin-2-yl)phenyl)cyclobutylcarbamate; 2,4-dibromobutanoyl chloride; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 20h;

With sodium hydrogencarbonate; In tetrahydrofuran; for 24h; Reflux;

Reference yield:

: 1313440-74-2
tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

: 1313440-73-1
tert-butyl 1-(4-(3-(2-hydroxyethyl)-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: With acetic acid; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 1313440-74-2
tert-butyl 1-(4-(7-phenyl-3,3a-dihydro-2H-furo[2,3-e]pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

: 1313440-83-3
tert-butyl 1-(4-(3-(2-hydroxyethyl)-1-methyl-2-oxo-7-phenyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl)phenyl)cyclobutylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / dichloromethane / 48 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

With potassium carbonate; acetic acid; In dichloromethane; N,N-dimethyl-formamide;