methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

Base Information

Chemical Name:methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate
CAS No.:144876-92-6
Molecular Formula:C₃₂H₃₈N₆O₆
Molecular Weight:602.69
Hs Code.:

Synonyms:methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

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Chemical Property of methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

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Technology Process of methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

There total 12 articles about methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 144876-88-0
4-methyl -N-<<1-<<<<2-<(2-amino-2-phenylethyl)amino>-1-(1H-indol-3-ylmethyl)-2-oxoethyl>amino>carbonyl>amino>cyclohexyl>carbonyl>-L-aspartate

: 144876-92-6
methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

Guidance literature:: With diphenyl-phosphinic acid; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 25 ℃; for 72h;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 17191-43-4
1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid

: 144876-92-6
methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

Guidance literature:: Multi-step reaction with 8 steps

1: 68 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / acetonitrile; dimethylformamide / 24 h / Ambient temperature

2: 99 percent / H₂ / 20percent Pd(OH)2/C / propan-2-ol / 17 h / 25 °C / 2327.2 Torr

3: 96 percent / NEt₃ / tetrahydrofuran / 25 °C

4: 81 percent / toluene; tetrahydrofuran / 16 h / 80 - 100 °C

5: 95 percent / TFA / CH₂Cl₂ / 17 h / 25 °C

6: 80 percent / BOP, i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

7: 1.1 g / H₂ / 20percent Pd(OH)2/C / petroleum ether / 12 h / 25 °C / 2327.2 Torr

8: 63 percent / DPPA, NaHCO₃ / dimethylformamide / 72 h / 25 °C

With dmap; diphenyl-phosphinic acid; hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium dihydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene; acetonitrile; Petroleum ether;
DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

: 51298-61-4
(S)-1-benzyl 4-methyl 2-aminosuccinate

: 144876-92-6
methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / BOP, i-Pr₂NEt / dimethylformamide / 12 h / 25 °C

2: 1.1 g / H₂ / 20percent Pd(OH)2/C / petroleum ether / 12 h / 25 °C / 2327.2 Torr

3: 63 percent / DPPA, NaHCO₃ / dimethylformamide / 72 h / 25 °C

With diphenyl-phosphinic acid; hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In N,N-dimethyl-formamide; Petroleum ether;
DOI:10.1016/S0040-4020(01)86596-0