1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

Base Information

• Chemical Name: 1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester
• CAS No.: 144876-65-3
• Molecular Formula: C₁₂H₂₅NO₂Si
• Molecular Weight: 243.421
• Mol file: 144876-65-3.mol

Synonyms:1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

Chemical Property of 1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

There total 2 articles about 1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester (144876-64-2) → 1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester (144876-65-3)

Guidance literature:

With hydrogen; palladium dihydroxide; In isopropyl alcohol; at 25 ℃; for 17h; under 2327.2 Torr;

DOI:10.1016/S0040-4020(01)86596-0

Reference yield:

1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid (17191-43-4) → 1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester (144876-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 68 percent / dicyclohexylcarbodiimide, 4-dimethylaminopyridine / acetonitrile; dimethylformamide / 24 h / Ambient temperature

2: 99 percent / H₂ / 20percent Pd(OH)2/C / propan-2-ol / 17 h / 25 °C / 2327.2 Torr

With dmap; hydrogen; dicyclohexyl-carbodiimide; palladium dihydroxide; In N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;

DOI:10.1016/S0040-4020(01)86596-0

Reference yield: 96.0%

bis(trichloromethyl) carbonate (32315-10-9) + 1-Amino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester (144876-65-3) → 2-(trimethylsilyl)ethyl-1-isocyanato-1-cyclohexane carboxylate (144876-60-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 25 ℃;

DOI:10.1016/S0040-4020(01)86596-0

upstream raw materials:

1-Benzyloxycarbonylamino-cyclohexanecarboxylic acid 2-trimethylsilanyl-ethyl ester

1-{[(benzyloxy)carbonyl]amino}cyclohexanecarboxylic acid

Downstream raw materials:

2-(trimethylsilyl)ethyl-1-isocyanato-1-cyclohexane carboxylate

<10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-pentaazaspiro<5,13>nonadecane-17-acetic acid

methyl <10R-(10α,14β,17α)>-10-(1H-indol-3-ylmethyl)-8,11,16,19-tetraoxo-14-phenyl-7,9,12,15,18-petaazaspiro<5,13>nonadecane-17-acetate

phenylmethyl -<2-<<3-(1H-indol-3-yl)-2-<(4-oxo-3-oxa-1-azaspiro<4.5>dec-1-en-2-yl)amino>-1-oxopropyl>amino>-1-phenylethyl>carbamate