5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide

Base Information

Chemical Name:5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide
CAS No.:747414-51-3
Molecular Formula:C₃₀H₃₂N₂O₄
Molecular Weight:484.595
Hs Code.:

Synonyms:5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide

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Chemical Property of 5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide

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Technology Process of 5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide

There total 8 articles about 5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.19%

: 747413-71-4
5-(2,4-bis(benzyloxy)-5-bromophenyl)isoxazole-3-carboxylic acid ethylamide

: 84110-40-7
Dihydroxy-isobutyl-boran

: 747414-51-3
5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In water; toluene; at 25 - 120 ℃; for 18h; Inert atmosphere;

Reference yield:

: 747414-50-2
5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethyl ester

: 75-04-7,85404-22-4
ethylamine

: 747414-51-3
5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: In methanol; at 120 ℃; for 0.166667h; microwave irradiation;
DOI:10.1021/jm701018h

Reference yield:

: 22877-01-6
2,4-bis(benzyloxy)acetophenone

: 747414-51-3
5-(2,4-bis(benzyloxy)-5-isobutylphenyl)isoxazole-3-carboxylic acid ethylamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / N,N-dimethyl-formamide / 3 h / 0 - 25 °C / Inert atmosphere

2: sodium ethanolate / ethanol / 2 h

3: hydroxylamine hydrochloride / ethanol

4: ethanol

5: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; toluene / 18 h / 25 - 120 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; hydroxylamine hydrochloride; sodium ethanolate; sodium carbonate; In ethanol; water; N,N-dimethyl-formamide; toluene;