146328-85-0

Basic information

• Product Name: 5-Bromo-2-fluorobenzoic acid
• Synonyms: RARECHEM AL BO 0757;2-FLUORO-5-BROMOBENZOIC ACID;5-BROMO-2-FLUOROBENZOIC ACID;BUTTPARK 19\01-67;5-Bromo-2-Fluorobenzoic Acid 2-Fluoro-5-Bromobenzoic Acid;5-Bromo-2-fluorobenzoic;5-Bromo-2-fluorobenzoic acid 97%;5-Bromo-2-fluorobenzoicacid97%
• CAS NO: 146328-85-0
• Molecular Formula: C₇H₄BrFO₂
• Molecular Weight: 219.01
• EINECS: 604-519-9
• Product Categories: Fluorin-contained Benzoic acid series;blocks;Bromides;Carboxes;FluoroCompounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Benzoic acid;Miscellaneous;Acids & Esters;Bromine Compounds;Fluorine Compounds;C7;Carbonyl Compounds;Carboxylic Acids;Benzoic acid series;Fluorine series
• Mol File: 146328-85-0.mol
• Article Data: 11

Chemical Properties

• Melting Point: 141-145 °C(lit.)
• Boiling Point: 296.5 °C at 760 mmHg
• Flash Point: 133.1 °C
• Appearance: /
• Density: 1.789 g/cm³
• Vapor Pressure: 0.000644mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.88±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-Bromo-2-fluorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-fluorobenzoic acid(146328-85-0)
• EPA Substance Registry System: 5-Bromo-2-fluorobenzoic acid(146328-85-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22
• Safety Statements: 26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 146328-85-0(Hazardous Substances Data)

Usage

Chemical Properties

White solid

Uses

5-Bromo-2-fluorobenzoic acid is used as a pharmaceutical and organic intermediate.

InChI:InChI=1/C7H4BrFO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11)/p-1

Upstream product

• 445-29-4 o-fluoro-benzoic acid 
• 93777-26-5 5-bromo-2-fluorobenzaldehyde 
• 124-38-9 carbon dioxide 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 146328-84-9 4-fluoro-[1,1'-biphenyl]-3-carboxylic acid 
• 247569-37-5 5-bromo-N-(3,4-dimethoxybenzyl)-2-fluorobenzamide 
• 247568-34-9 2-fluoro-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 
• 247570-14-5 5-bromo-N-(4-chloro-3-methoxybenzyl)-2-fluorobenzamide 
• 935285-60-2 tert-butyl (5-bromo-2-fluorophenyl)carbamate 
• 612835-53-7 ethyl 5-bromo-2-fluorobenzoate 
• 1333071-86-5 C₁₇H₁₈BrFO 
• 1206774-43-7 1-(5-bromo-2-fluorophenyl)-1-methylethanol 
• 1318793-75-7 1-deoxy-1-{3-[1-(4-ethoxyphenyl)-1-methylethyl]-4-fluorophenyl}-β-D-glucopyranose 
• 1333071-87-6 2,3,4,6-tetra-O-acetyl-1-deoxy-1-{3-[1-(4-ethoxyphenyl)-1-methylethyl]-4-fluorophenyl}-β-D-glucopyranose 
• 206257-39-8 6-bromo-4-chloroquinoline-3-carboxylic acid ethyl ester 
• 1248546-11-3 ethyl 6-bromo-1-[(4-methoxyphenyl)methyl]-4-oxoquinoline-3-carboxylate 
• 1821428-35-6 AZD0156 
• 247568-40-7 (S)-2-[1-(tert-butoxycarbonyl)ethylamino]-5-nitro-N-(1,3-benzodioxol-5-ylmethyl)benzamide 

Relevant articles and documents

Synthesis method of 2-halo-5-bromobenzoic acid

The invention discloses a synthesis method of 2-halo-5-bromobenzoic acid. The method comprises the following steps of under the action of sulfuric acid, carrying out a bromination reaction on o-halo-benzoic acid and NBS in an organic solvent, and after the reaction is finished, carrying out posttreatment to obtain 2-halo-5-bromobenzoic acid. The method has the advantages of being short in reactionroute, simple in operation, environmentally friendly, safe and economical and has a broad application prospect.

TRIAZOLONES DERIVATIVES FOR USE IN THE TREATMENT, AMELIORATION OR PREVENTION OF A VIRAL DISEASE

The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, codrug, cocrystal, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.

Synthesis and structural characterization of new phosphinooxazoline complexes of iron

The first phosphinooxazoline chelate complexes of iron were synthesized, and their structural and electronic properties were studied. The known phosphinooxazolines 2-(2-(diphenylphosphino)phenyl)-4,5-dihydrooxazole (7a), 2-(2-(diphenylphosphino)phenyl)-4,