(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one

Base Information

Chemical Name:(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one
CAS No.:1267800-39-4
Molecular Formula:C₁₁H₁₃FN₂O₂
Molecular Weight:224.235
Hs Code.:

Synonyms:(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one

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Chemical Property of (R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one

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Technology Process of (R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one

There total 10 articles about (R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1013-88-3
Benzophenone imine

: 1266785-04-9
(5R)-5-(5-bromo-2-fluorophenyl)-5-methylmorpholin-3-one

: 1267800-39-4
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one

Guidance literature:: With sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In toluene; at 105 ℃; for 18h;

Reference yield:

: 146328-85-0
5-bromo-2-fluoro-benzoic acid

: 1267800-39-4
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 10 steps

1: N,0-dimethylhydroxylamine; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dmap / dichloromethane / 16 h / 20 °C

2: methylmagnesium chloride / tetrahydrofuran / 0.33 h / 12 - 16 °C / Reflux

3: potassium cyanide / ethanol / 16 h / 120 °C / Autoclave

4: sodium hydroxide / water

5: thionyl chloride

6: lithium aluminium tetrahydride / tetrahydrofuran

7: acetonitrile

8: Reprosil Chiral NR / dichloromethane / Resolution of racemate

9: potassium tert-butylate

10: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 18 h / 105 °C

With potassium cyanide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; methylmagnesium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; sodium t-butanolate; N,0-dimethylhydroxylamine; tert-butyl XPhos; dmap; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1267800-39-4
(R)-5-(5-amino-2-fluoro-phenyl)-5-methyl-morpholin-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: potassium cyanide / ethanol / 16 h / 120 °C / Autoclave

2: sodium hydroxide / water

3: thionyl chloride

4: lithium aluminium tetrahydride / tetrahydrofuran

5: acetonitrile

6: Reprosil Chiral NR / dichloromethane / Resolution of racemate

7: potassium tert-butylate

8: sodium t-butanolate; tert-butyl XPhos / tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex / toluene / 18 h / 105 °C

With potassium cyanide; lithium aluminium tetrahydride; thionyl chloride; potassium tert-butylate; sodium hydroxide; sodium t-butanolate; tert-butyl XPhos; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; acetonitrile;