4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid

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Chemical Name:4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid
CAS No.:1387641-36-2
Molecular Formula:C₂₁H₁₉ClN₂O₇
Molecular Weight:446.844
Hs Code.:

Synonyms:4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid

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Chemical Property of 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid

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Technology Process of 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid

There total 7 articles about 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1387641-35-1
methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

: 1387641-36-2
4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid

Guidance literature:: methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate; With water; sodium hydroxide; In methanol; at 65 ℃; for 3h;

In methanol; pH=2; Acidic conditions;

Reference yield:

: 621-59-0
isovanillin

: 1387641-36-2
4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 85 °C

2.1: nitric acid / acetic acid / 0.08 h / Cooling with ice

2.2: 4 h / 20 °C / Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

4.1: piperidine / acetic acid / methanol / 60 °C

5.1: sodium hydroxide; water / methanol / 4 h / 60 °C

5.2: pH 3 / Acidic conditions

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

7.1: sodium hydroxide; water / methanol / 3 h / 65 °C

7.2: pH 2 / Acidic conditions

With piperidine; water; hydrogen; nitric acid; potassium carbonate; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; potassium iodide; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 4-methoxy-5-(2-methoxy-ethoxy)-2-nitro-benzaldehyde

: 1387641-36-2
4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

2.1: piperidine / acetic acid / methanol / 60 °C

3.1: sodium hydroxide; water / methanol / 4 h / 60 °C

3.2: pH 3 / Acidic conditions

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: sodium hydroxide; water / methanol / 3 h / 65 °C

5.2: pH 2 / Acidic conditions

With piperidine; water; hydrogen; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; In methanol; ethyl acetate; N,N-dimethyl-formamide;