N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide
CAS No.:1387641-37-3
Molecular Formula:C₂₈H₂₅Cl₂N₃O₆
Molecular Weight:570.429
Hs Code.:

Synonyms:N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide

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Chemical Property of N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide

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Technology Process of N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide

There total 8 articles about N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1387641-36-2
4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoic acid

: 4152-90-3
m-chlorobenzylamine

: 1387641-37-3
N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; for 14h;

Reference yield:

: 621-59-0
isovanillin

: 1387641-37-3
N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 85 °C

2.1: nitric acid / acetic acid / 0.08 h / Cooling with ice

2.2: 4 h / 20 °C / Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

4.1: piperidine / acetic acid / methanol / 60 °C

5.1: sodium hydroxide; water / methanol / 4 h / 60 °C

5.2: pH 3 / Acidic conditions

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

7.1: sodium hydroxide; water / methanol / 3 h / 65 °C

7.2: pH 2 / Acidic conditions

8.1: triethylamine; HATU / N,N-dimethyl-formamide / 14 h

With piperidine; water; hydrogen; nitric acid; potassium carbonate; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; potassium iodide; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 4-methoxy-5-(2-methoxy-ethoxy)-2-nitro-benzaldehyde

: 1387641-37-3
N-(2-chloro-5-(3-chlorobenzylcarbamoyl)phenyl)-7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

2.1: piperidine / acetic acid / methanol / 60 °C

3.1: sodium hydroxide; water / methanol / 4 h / 60 °C

3.2: pH 3 / Acidic conditions

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

5.1: sodium hydroxide; water / methanol / 3 h / 65 °C

5.2: pH 2 / Acidic conditions

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 14 h

With piperidine; water; hydrogen; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; In methanol; ethyl acetate; N,N-dimethyl-formamide;