methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

Base Information

Chemical Name:methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
CAS No.:1387641-35-1
Molecular Formula:C₂₂H₂₁ClN₂O₇
Molecular Weight:460.871
Hs Code.:

Synonyms:methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

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Chemical Property of methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

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Technology Process of methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

There total 6 articles about methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1387641-64-6
7-methoxy-6-(2-methoxy-ethoxy)-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid

: 1387641-35-1
methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 18h; Product distribution / selectivity;

Reference yield:

: 621-59-0
isovanillin

: 1387641-35-1
methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / potassium iodide / N,N-dimethyl-formamide / 85 °C

2.1: nitric acid / acetic acid / 0.08 h / Cooling with ice

2.2: 4 h / 20 °C / Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

4.1: piperidine / acetic acid / methanol / 60 °C

5.1: sodium hydroxide; water / methanol / 4 h / 60 °C

5.2: pH 3 / Acidic conditions

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With piperidine; water; hydrogen; nitric acid; potassium carbonate; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; potassium iodide; In methanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 4-methoxy-5-(2-methoxy-ethoxy)-2-nitro-benzaldehyde

: 1387641-35-1
methyl 4-chloro-3-(7-methoxy-6-(2-methoxyethoxy)-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 1551.49 Torr

2.1: piperidine / acetic acid / methanol / 60 °C

3.1: sodium hydroxide; water / methanol / 4 h / 60 °C

3.2: pH 3 / Acidic conditions

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h / 20 °C

With piperidine; water; hydrogen; triethylamine; HATU; sodium hydroxide; palladium 10% on activated carbon; acetic acid; In methanol; ethyl acetate; N,N-dimethyl-formamide;