Technology Process of 4-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]benzonitrile
There total 2 articles about 4-[4-(thiophen-3-yl)-1H-1,2,3-triazol-1-yl]benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(ll) sulfate pentahydrate; sodium L-ascorbate;
In
water; tert-butyl alcohol;
at 20 ℃;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b00275
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium azide / N,N,N,N,N,N-hexamethylphosphoric triamide / 4 h / 20 °C / Inert atmosphere
2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 20 °C / Inert atmosphere
With
sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; water; tert-butyl alcohol;
DOI:10.1021/acs.orglett.7b00275
- Guidance literature:
-
With
N-Bromosuccinimide;
In
1,2-dichloro-ethane;
at 20 ℃;
for 18h;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b00275
