mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester

Base Information

• Chemical Name: mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester
• CAS No.: 1456890-69-9
• Molecular Formula: C₂₀H₂₁NO₈
• Molecular Weight: 403.389
• Mol file: 1456890-69-9.mol

Synonyms:mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester

Chemical Property of mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester

There total 4 articles about mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-hydroxy-2-methylidene-3-phenylpropionate (18020-59-2) + 5-[(2',5'-dioxo-1'-pyrrolidinyl)oxy]-5-oxopentanoyl chloride (117746-42-6) → mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester (1456890-69-9)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1039/c3cc43271h

Reference yield:

benzaldehyde (100-52-7) → mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester (1456890-69-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / methanol / 48 h / 20 °C / Darkness

2: pyridine / dichloromethane / 4 h / 0 - 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; In methanol; dichloromethane;

DOI:10.1039/c3cc43271h

Reference yield:

glutaric anhydride, (108-55-4) → mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester (1456890-69-9)

Guidance literature:

Multi-step reaction with 3 steps

1: dmap / tetrahydrofuran / 4 h / 0 - 20 °C

2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

3: pyridine / dichloromethane / 4 h / 0 - 20 °C

With pyridine; dmap; thionyl chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c3cc43271h

upstream raw materials:

benzaldehyde

methyl 3-hydroxy-2-methylidene-3-phenylpropionate

5-[(2',5'-dioxo-1'-pyrrolidinyl)oxy]-5-oxopentanoyl chloride

glutaric anhydride,

Downstream raw materials:

mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide