mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide

Base Information

• Chemical Name: mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide
• CAS No.: 1456890-68-8
• Molecular Formula: C₂₆H₃₄N₂O₁₁
• Molecular Weight: 550.563
• Mol file: 1456890-68-8.mol

Synonyms:mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide

Chemical Property of mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide

There total 4 articles about mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester (1456890-69-9) + N,N-bis(carboxymethyl)-L-lysine (113231-05-3) → mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide (1456890-68-8)

Guidance literature:

With triethylamine; In methanol; at 0 - 20 ℃;

DOI:10.1039/c3cc43271h

Reference yield:

benzaldehyde (100-52-7) → mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide (1456890-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / methanol / 48 h / 20 °C / Darkness

2: pyridine / dichloromethane / 4 h / 0 - 20 °C

3: triethylamine / methanol / 0 - 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; triethylamine; In methanol; dichloromethane;

DOI:10.1039/c3cc43271h

Reference yield:

glutaric anhydride, (108-55-4) → mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid 5S-carboxy-5-[bis(hydroxycarbonylmethyl)amino]pentylamide (1456890-68-8)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap / tetrahydrofuran / 4 h / 0 - 20 °C

2: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

3: pyridine / dichloromethane / 4 h / 0 - 20 °C

4: triethylamine / methanol / 0 - 20 °C

With pyridine; dmap; thionyl chloride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c3cc43271h

upstream raw materials:

mono(1-phenyl-2-methoxycarbonyl-2-propenyl)glutaric acid N-hydroxy succinimide ester

N,N-bis(carboxymethyl)-L-lysine

benzaldehyde

glutaric anhydride,