3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester

Base Information

• Chemical Name: 3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester
• CAS No.: 951313-27-2
• Molecular Formula: C₁₈H₂₂FNO₅
• Molecular Weight: 351.375

Synonyms:3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester

Chemical Property of 3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester

Chemical Property:

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Technology Process of 3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester

There total 1 articles about 3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,4-difluoro-3-methoxybenzoyl)-3-dimethylaminoacrylic acid ethyl ester + 2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-dimethylaminoacrylic acid ethyl ester + Cyclopropylamine (765-30-0) → 3-cyclopropylamino-2-(2,4-difluoro-3-methoxybenzoyl)-3-acrylic acid ethyl ester (951313-24-9) + 3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester (951313-27-2)

Guidance literature:

In toluene; at 20 ℃; for 0.5h;

Reference yield: 82.0%

3-cyclopropylamino-2-(2,4-difluoro-3-methoxybenzoyl)-3-acrylic acid ethyl ester (951313-24-9) + 3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester (951313-27-2) → ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate (221221-15-4)

Guidance literature:

With N,O-Bis(trimethylsilyl)acetamide; In toluene; at 20 - 115 ℃; for 1h; Heating / reflux;

Reference yield: 82.0%

3-cyclopropylamino-2-(2,4-difluoro-3-methoxybenzoyl)-3-acrylic acid ethyl ester (951313-24-9) + 3-cyclopropylamino-2-(2-ethoxy-3-methoxy-4-fluorobenzoyl)-3-acrylic acid ethyl ester (951313-27-2) + N,O-bis-(trimethylsilyl)-acetamide (10416-59-8) → ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate (221221-15-4)

Guidance literature:

In toluene; at 105 - 115 ℃; for 0.5h;

upstream raw materials:

Cyclopropylamine

Downstream raw materials:

ethyl cyclopropyl-4-oxo-7-fluoro-8-methoxy-1,4-dihydroquinolin-3-carboxylate

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