(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline

Base Information

Chemical Name:(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline
CAS No.:875014-50-9
Molecular Formula:C₂₉H₃₈N₂O₃
Molecular Weight:462.632
Hs Code.:

Synonyms:(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline

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Chemical Property of (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline

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Technology Process of (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline

There total 5 articles about (16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 875014-49-6
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)pyrazoline

: 75-36-5
acetyl chloride

: 875014-50-9
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline

Guidance literature:: at 20 ℃;
DOI:10.1016/j.bmc.2005.08.024

Reference yield:

: 1058-58-8
16-(4-methoxy-benzylidene)-5α-androstan-3β-ol-17-one

: 875014-50-9
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 5 h / Heating

2: 80 percent / dimethylsulfoxide; trifluoroacetic acid; dicyclohexylcarbodiimide / pyridine / benzene / 20 °C

3: 60 percent / 20 °C

With hydrazine hydrate; dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; pyridine; In ethanol; benzene; 2: Moffat oxidation;
DOI:10.1016/j.bmc.2005.08.024

Reference yield:

: 875014-48-5
(16R,5'S)(8β,9α,14α)-3β-hydroxy-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)pyrazoline

: 875014-50-9
(16R,5'S)(8β,9α,14α)-3-oxo-5α-androstano[17,16-c]-1'H-5'-(p-methoxyphenyl)-N-acetylpyrazoline

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / dimethylsulfoxide; trifluoroacetic acid; dicyclohexylcarbodiimide / pyridine / benzene / 20 °C

2: 60 percent / 20 °C

With dimethyl sulfoxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; pyridine; In benzene; 1: Moffat oxidation;
DOI:10.1016/j.bmc.2005.08.024