1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate

Base Information

Chemical Name:1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate
CAS No.:104330-74-7
Molecular Formula:C₂₁H₂₈NSi*ClO₄
Molecular Weight:421.996
Hs Code.:

Synonyms:1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate

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Chemical Property of 1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate

Chemical Property:

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Technology Process of 1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate

There total 8 articles about 1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 104330-70-3
1-(o-((trimethylsilyl)methyl)benzyl)-3,4-dihydroisoquiniline

: 74-88-4
methyl iodide

: 104330-74-7
1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate

Guidance literature:: With silver perchlorate; In acetonitrile;
DOI:10.1016/S0040-4039(00)98248-0

Reference yield:

: 3230-65-7
3,4-dihydroisoquinoline

: 104330-74-7
1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate

Guidance literature:: Multi-step reaction with 3 steps

1: magnesium / 1.) ether, reflux, 1 h, 2.) reflux, 4 h

2: 1.) N-chlorosuccinimide, 2.)KOH / 1.) ether, 25 deg C, 0.5 h, 2.) methanol, 25 deg C, 1 h

3: 66 percent / silver perchlorate / acetonitrile / 2 h / 25 °C

With potassium hydroxide; N-chloro-succinimide; silver perchlorate; magnesium; In acetonitrile;
DOI:10.1021/jo00256a038

Reference yield:

: 57754-01-5
2-[(trimethylsilyl)methyl]benzyl alcohol

: 104330-74-7
1-(o-((trimethylsilyl)methyl)benzyl)-2-methyl-3,4-dihydroisoquinolinium perchlorate

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / triphenylphosphine / CCl₄ / 4 h / Heating

2: magnesium / 1.) ether, reflux, 1 h, 2.) reflux, 4 h

3: 1.) N-chlorosuccinimide, 2.)KOH / 1.) ether, 25 deg C, 0.5 h, 2.) methanol, 25 deg C, 1 h

4: 66 percent / silver perchlorate / acetonitrile / 2 h / 25 °C

With potassium hydroxide; N-chloro-succinimide; silver perchlorate; magnesium; triphenylphosphine; In tetrachloromethane; acetonitrile;
DOI:10.1021/jo00256a038