1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol

Base Information

• Chemical Name: 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol
• CAS No.: 956093-19-9
• Molecular Formula: C₃₈H₄₉N₂O₆P
• Molecular Weight: 660.791
• Mol file: 956093-19-9.mol

Synonyms:1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol

Chemical Property of 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol

There total 2 articles about 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol (956093-18-8) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol (956093-19-9)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jo8009837

Reference yield: 92.0%

→ 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol (956093-19-9)

Guidance literature:

Reference yield:

1-O-[[4-(azidomethyl)cyclohexyl]methyl]-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside (1044273-67-7) + 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol (956093-19-9) + 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] (98796-51-1) + 1-O-(3-azidopropyl)-2,3,4,6-tetra-O-acetyl-β-D-galactopyranoside (819053-49-1) → C44H74N8O27P2 (1043911-68-7) + C49H82N8O27P2 (1044273-72-4) + C49H82N8O27P2 (1044273-71-3) + C54H90N8O27P2 (1044273-73-5)

Guidance literature:

Multistep reaction. Title compound not separated from byproducts.;

DOI:10.1021/jo8009837

upstream raw materials:

1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol

N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

Downstream raw materials:

C₄₄H₇₄N₈O₂₇P₂

C₄₉H₈₂N₈O₂₇P₂

C₄₉H₈₂N₈O₂₇P₂

C₅₄H₉₀N₈O₂₇P₂