1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol

Base Information

• Chemical Name: 1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol
• CAS No.: 956093-18-8
• Molecular Formula: C₂₉H₃₂O₅
• Molecular Weight: 460.57

Synonyms:1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol

Chemical Property of 1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol

Chemical Property:

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Technology Process of 1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol

There total 1 articles about 1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-[(4,4’-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol (327029-56-1) + propargyl bromide (106-96-7) → 1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol (956093-18-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; toluene; at 20 ℃; for 1h;

DOI:10.1021/jo702177c

Reference yield: 92.0%

1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol (956093-18-8) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol (956093-19-9)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jo8009837

Reference yield:

1-O-propargyl-2-[(4,4'-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol (956093-18-8) + diphenyl hydrogen phosphite (4712-55-4) → C35H37O7P

Guidance literature:

With pyridine; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1039/c1cc12428e

upstream raw materials:

2-[(4,4’-dimethoxytrityl)oxymethyl]-2-methylpropane-1,3-diol

propargyl bromide

Downstream raw materials:

1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]-1,3-propanediol

triethylammonium 1-O-(4,4'-dimethoxytrityl)-2-propargyloxymethyl-2-methyl-3-O-hydrogenphosphate-1,3-propanediol

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