N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Base Information

Chemical Name:N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide
CAS No.:1491169-38-0
Molecular Formula:C₂₀H₁₂F₈N₂O₂S
Molecular Weight:496.381
Hs Code.:

Synonyms:N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Chemical Property:

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Technology Process of N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

There total 6 articles about N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: (4-(2,6-difluorophenyl)pyridin-3-yl)methanamine dihydrochloride

: 39234-86-1
3,5-bis(trifluoromethyl)benzenesulfonyl chloride

: 1491169-38-0
N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: C₁₂H₉F₂NO

: 1491169-38-0
N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

2: triphenylphosphine / water; tetrahydrofuran / 20 °C

3: hydrogenchloride

4: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 2: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050

Reference yield:

: 162101-25-9
2,6-difluorophenylboronic acid

: 1491169-38-0
N-((4-(2,6-difluorophenyl)pyridin-3-yl)methyl)-3,5-bis(trifluoromethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine / hexane; toluene / 36 h / Inert atmosphere; Reflux

2: diisobutylaluminium hydride / toluene; dichloromethane / 1.5 h / -78 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene; diphenyl phosphoryl azide / tetrahydrofuran / 5 h / Reflux; Inert atmosphere

4: triphenylphosphine / water; tetrahydrofuran / 20 °C

5: hydrogenchloride

6: triethylamine / dichloromethane / 20 °C

With hydrogenchloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tri-tert-butyl phosphine; diphenyl phosphoryl azide; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane; water; toluene; 1: |Suzuki Coupling / 4: |Staudinger Azide Reduction;
DOI:10.1016/j.ejmech.2013.07.050