tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate

Base Information

• Chemical Name: tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate
• CAS No.: 1161026-84-1
• Molecular Formula: C₂₀H₃₁N₃O₄
• Molecular Weight: 377.484

Synonyms:tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate

Chemical Property of tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate

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Technology Process of tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate

There total 1 articles about tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester (98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2) + (S)-5-aminomethyl-2-pyrrolidone (145414-31-9) → tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate (1161026-84-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 65 ℃; for 18h; Inert atmosphere;

DOI:10.1021/jm900303m

Reference yield: 100.0%

tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate (1161026-84-1) + 4-methoxy-phenyl-sulphonyl chloride (98-68-0) → tert-butyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate (1053613-59-4)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; for 12h;

DOI:10.1021/jm900303m

Reference yield: 80.0%

tert-butyl (2S,3R)-3-hydroxy-4-[((S)-5-oxopyrrolidin-2-yl)-methylamino]-1-phenylbutan-2-ylcarbamate (1161026-84-1) + 4-Nitrobenzenesulfonyl chloride (98-74-8) → C26H34N4O8S (1053622-34-6)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; for 7h;

DOI:10.1021/jm900303m

upstream raw materials:

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

(S)-5-aminomethyl-2-pyrrolidone

Downstream raw materials:

tert-butyl (2S,3R)-3-hydroxy-4-(4-methoxy-N-(((S)-5-oxopyrrolidin-2-yl)methyl)phenylsulfonamido)-1-phenylbutan-2-ylcarbamate

C₂₆H₃₄N₄O₈S

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