(R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

Base Information

Chemical Name:(R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate
CAS No.:1313485-90-3
Molecular Formula:C₄₂H₆₃N₃O₅Si
Molecular Weight:718.065
Hs Code.:

Synonyms:(R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

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Chemical Property of (R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

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Technology Process of (R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

There total 4 articles about (R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 743460-24-4
Biphenyl-2-ylcarbamic Acid 1-(9-Oxononyl)piperidin-4-yl Ester

: 1313485-89-0
(R)-4-(2-amino-1-hydroxyethyl)-2-[[(tert-butyldimethylsilyl)oxy]methyl]phenol

: 1313485-90-3
(R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

Guidance literature:: Biphenyl-2-ylcarbamic Acid 1-(9-Oxononyl)piperidin-4-yl Ester; (R)-4-(2-amino-1-hydroxyethyl)-2-[[(tert-butyldimethylsilyl)oxy]methyl]phenol; With acetic acid; In dichloromethane; at 0 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1313485-90-3
(R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: acetic acid / dichloromethane / 0.5 h / 0 °C

3.2: 2 h / 0 - 20 °C

With 1H-imidazole; sodium azide; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 324556-92-5
(R)-(+)-2-bromo-1-(3'-hydroxymethyl-4'-benzyloxyphenyl) ethanol

: 1313485-90-3
(R)-1-[9-[[2-[3-[[(tert-butyldimethylsilyl)oxy]methyl]-4-hydroxyphenyl]-2-hydroxyethyl]amino]nonyl]piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / dichloromethane / 1 h / 20 °C

2.1: sodium azide / N,N-dimethyl-formamide / 4 h / 80 °C

3.1: acetic acid / dichloromethane / 0.5 h / 0 °C

3.2: 2 h / 0 - 20 °C

With 1H-imidazole; sodium azide; acetic acid; In dichloromethane; N,N-dimethyl-formamide;