2-Chloro-6-trifluoroMethyl-nicotinic acid Methyl ester

Base Information

• Chemical Name: 2-Chloro-6-trifluoroMethyl-nicotinic acid Methyl ester
• CAS No.: 1073129-57-3
• Molecular Formula: C₈H₅ClF₃NO₂
• Molecular Weight: 239.581
• Hs Code.: 2933399990
• Mol file: 1073129-57-3.mol

Synonyms:2-chloro-6-trifluoromethylnicotinic acid methyl ester

Chemical Property of 2-Chloro-6-trifluoroMethyl-nicotinic acid Methyl ester

Chemical Property:

• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-Chloro-6-(trifluoromethyl)nicotinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-6-trifluoroMethyl-nicotinic acid Methyl ester

There total 3 articles about 2-Chloro-6-trifluoroMethyl-nicotinic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl iodide (74-88-4) + 2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid (280566-45-2) → 2-chloro-6-trifluoromethylnicotinic acid methyl ester (1073129-57-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 21.5h;

Reference yield:

diazomethyl-trimethyl-silane (18107-18-1) + 2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid (280566-45-2) → 2-chloro-6-trifluoromethylnicotinic acid methyl ester (1073129-57-3)

Guidance literature:

In methanol; dichloromethane; at 25 ℃; for 1h;

Reference yield:

→ 2-chloro-6-trifluoromethylnicotinic acid methyl ester (1073129-57-3)

Guidance literature:

upstream raw materials:

methyl iodide

2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid

diazomethyl-trimethyl-silane

Downstream raw materials:

methyl 2-(3,4-dimethoxybenzylamino)-6-(trifluoromethyl)nicotinate

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