(S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

Base Information

• Chemical Name: (S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester
• CAS No.: 476374-18-2
• Molecular Formula: C₂₆H₂₆F₂N₄O₇
• Molecular Weight: 544.512

Synonyms:(S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

Chemical Property of (S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

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Technology Process of (S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester

There total 4 articles about (S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

diethyl-L-glutamate hydrochloride (1118-89-4) + 3-(4-carboxymethyl-phenylamino)-6,7-difluoro-quinoxaline-2-carboxylic acid (476374-12-6) → (S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester (476374-18-2)

Guidance literature:

With diethyl cyanophosphonate; triethylamine; at 20 ℃; for 2h;

DOI:10.1016/S0014-827X(01)01159-4

Reference yield:

ethyl (4-amino-3,5-dibromophenyl)acetate (5438-70-0) → (S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester (476374-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / ethanol / 24 h / Heating

2: 93 percent / aq. NaOH / ethanol / 4 h / Heating

3: 40 percent / (EtO)2POCN; Et₃N / 2 h / 20 °C

With sodium hydroxide; diethyl cyanophosphonate; triethylamine; In ethanol;

DOI:10.1016/S0014-827X(01)01159-4

Reference yield:

2-Chloro-6,7-difluoro-3-ethoxycarbonylquinoxaline (274686-96-3) → (S)-2-{2-[4-(3-Carboxy-6,7-difluoro-quinoxalin-2-ylamino)-phenyl]-acetylamino}-pentanedioic acid diethyl ester (476374-18-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 49 percent / ethanol / 24 h / Heating

2: 93 percent / aq. NaOH / ethanol / 4 h / Heating

3: 40 percent / (EtO)2POCN; Et₃N / 2 h / 20 °C

With sodium hydroxide; diethyl cyanophosphonate; triethylamine; In ethanol;

DOI:10.1016/S0014-827X(01)01159-4

upstream raw materials:

diethyl-L-glutamate hydrochloride

3-(4-carboxymethyl-phenylamino)-6,7-difluoro-quinoxaline-2-carboxylic acid

ethyl (4-amino-3,5-dibromophenyl)acetate

2-Chloro-6,7-difluoro-3-ethoxycarbonylquinoxaline

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