6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate

Base Information

Chemical Name:6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate
CAS No.:1430219-41-2
Molecular Formula:C₄₀H₄₉FN₄O₅
Molecular Weight:684.851
Hs Code.:

Synonyms:6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate

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Chemical Property of 6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate

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Technology Process of 6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate

There total 12 articles about 6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1430219-59-2
2-{2-fluoro-4'-[6-(nitrooxy)hexyloxy]biphenyl-4-yl}propanoic acid

: 249290-17-3
N₁-(1,2,3,4-tetrahydroacridin-9-yl)hexane-1,6-diamine

: 1430219-41-2
6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate

Guidance literature:: 2-{2-fluoro-4'-[6-(nitrooxy)hexyloxy]biphenyl-4-yl}propanoic acid; With dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 0.5h;

N₁-(1,2,3,4-tetrahydroacridin-9-yl)hexane-1,6-diamine; With dmap; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.bmc.2013.03.005

Reference yield:

: 113544-38-0,113544-39-1,114376-61-3,66202-86-6
methyl 2-(2-fluoro-4-biphenylyl)propionate

: 1430219-41-2
6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate

Guidance literature:: Multi-step reaction with 8 steps

1.1: aluminum (III) chloride / dichloromethane / Reflux

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C

3.1: sodium hydroxide / water; tetrahydrofuran; methanol / 2 h / 20 °C

4.1: sulfuric acid / 3 h / Reflux; Dean-Stark

5.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C

6.1: silver nitrate / acetonitrile / 6 h / 60 °C / Darkness

7.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 24 h / 20 °C

8.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

8.2: 24 h / 20 °C

With aluminum (III) chloride; lithium hydroxide monohydrate; sulfuric acid; potassium carbonate; silver nitrate; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1.1: |Friedel-Crafts Acylation / 2.1: |Baeyer-Villiger Ketone Oxidation;
DOI:10.1016/j.bmc.2013.03.005

Reference yield:

: 215175-84-1
methyl 2-(4′-acetoxy-2-fluoro-[1,1′-biphenyl]-4-yl)propanoate

: 1430219-41-2
6-{2'-fluoro-4'-[1-oxo-1-(6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexylamino)propan-2-yl]biphenyl-4-yloxy}hexyl nitrate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water; tetrahydrofuran; methanol / 2 h / 20 °C

2.1: sulfuric acid / 3 h / Reflux; Dean-Stark

3.1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 60 °C

4.1: silver nitrate / acetonitrile / 6 h / 60 °C / Darkness

5.1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 24 h / 20 °C

6.1: dicyclohexyl-carbodiimide / dichloromethane / 0.5 h / 20 °C

6.2: 24 h / 20 °C

With lithium hydroxide monohydrate; sulfuric acid; potassium carbonate; silver nitrate; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.03.005