methyl 2-(2-fluoro-4-biphenylyl)propionate

Base Information

• Chemical Name: methyl 2-(2-fluoro-4-biphenylyl)propionate
• CAS No.: 113544-38-0
• Molecular Formula: C₁₆H₁₅FO₂
• Molecular Weight: 258.292

Synonyms:

Chemical Property of methyl 2-(2-fluoro-4-biphenylyl)propionate

Chemical Property:

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MSDS Files:

SDS file from LookChem

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Technology Process of methyl 2-(2-fluoro-4-biphenylyl)propionate

There total 3 articles about methyl 2-(2-fluoro-4-biphenylyl)propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

C12H16FNO5S (1201594-47-9) + phenylboronic acid (98-80-6) → fluorobiprofen (5104-49-4) + methyl 2-(2-fluoro-4-biphenylyl)propionate (113544-38-0,113544-39-1,114376-61-3,66202-86-6)

Guidance literature:

With potassium phosphate; bis(tricyclohexylphosphine)nickel(II) dichloride; In toluene; at 130 ℃; for 24h; Inert atmosphere;

DOI:10.1021/ja906477r

Reference yield:

methanol (67-56-1) + fluorobiprofen (5104-49-4) → (S)-(+)-flurbiprofen (5104-49-4,51543-38-5,51543-39-6,51543-40-9) + (R)-flurbiprofen (5104-49-4,51543-38-5,51543-39-6,51543-40-9) + methyl 2-(2-fluoro-biphenyl-4-yl)propionate (113544-39-1) + methyl 2-(2-fluoro-biphenyl-4-yl)propionate (66202-86-6,113544-39-1,114376-61-3,113544-38-0)

Guidance literature:

In acetonitrile; at 45 ℃; for 48h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; immobilized lipase from Candida antarctica (Novozym 435);

DOI:10.1016/0957-4166(95)00223-C

Reference yield:

methanol (67-56-1) + (R)-3-O-(2-(2-fluoro-4-biphenyl)propionyl)-1,2-O-isopropylidene-α-D-glucofuranose (113544-32-4,113544-33-5) → 1,2-O-isopropylidene-α-D-gluco-/β-L-idofuranose (253328-56-2) + methyl 2-(2-fluoro-biphenyl-4-yl)propionate (66202-86-6,113544-39-1,114376-61-3,113544-38-0)

Guidance literature:

With potassium carbonate; at 20 ℃;

upstream raw materials:

methanol

(R)-3-O-(2-(2-fluoro-4-biphenyl)propionyl)-1,2-O-isopropylidene-α-D-glucofuranose

fluorobiprofen

C₁₂H₁₆FNO₅S

Downstream raw materials:

(R)-flurbiprofen

C₂₇H₁₉FN₂O₄S

fluorobiprofen

2-(2-fluoro-4-biphenylyl)-2-methylmalonic acid

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