(2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide

Base Information

Chemical Name:(2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide
CAS No.:1448667-91-1
Molecular Formula:C₃₂H₃₆N₄O₄S
Molecular Weight:572.728
Hs Code.:

Synonyms:(2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide

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Chemical Property of (2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide

Chemical Property:

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Technology Process of (2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide

There total 10 articles about (2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 3984-14-3
N,N-dimethylsulfamide

: 1448667-68-2
(2S,4R)-4-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxylic acid

: 1448667-91-1
(2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

Reference yield:

: 1871-76-7
diphenylacetic acid chloride

: 1448667-91-1
(2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 0.25 h / 0 °C

2: 10% palladium hydroxide on charcoal; hydrogen / isopropyl alcohol / 30 °C

3: caesium carbonate / N,N-dimethyl-formamide / 35 °C

4: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

5: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C

With dmap; lithium hydroxide monohydrate; 10% palladium hydroxide on charcoal; water; hydrogen; caesium carbonate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1799811-83-8
1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate

: 1448667-91-1
(2S,4R)-N-(N,N-dimethylsulfamoyl)-1-(2,2-diphenylacetyl)-4-(methyl(3-phenylprop-2-yn-1-yl)amino)piperidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid / methanol / 1 h / 20 °C

1.2: 0 - 20 °C

2.1: hydrogenchloride / methanol / 20 °C

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C

4.1: 10% palladium hydroxide on charcoal; hydrogen / isopropyl alcohol / 30 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 35 °C

6.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

7.1: dicyclohexyl-carbodiimide; dmap / dichloromethane / 20 °C

With hydrogenchloride; dmap; lithium hydroxide monohydrate; 10% palladium hydroxide on charcoal; water; hydrogen; caesium carbonate; acetic acid; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;