tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

Base Information

Chemical Name:tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate
CAS No.:1345718-94-6
Molecular Formula:C₂₁H₃₀FNO₃
Molecular Weight:363.473
Hs Code.:

Synonyms:tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

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Technology Process of tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

There total 3 articles about tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: C₁₅H₂₀FNO₂

: 86302-43-4,35000-38-5
(tert-Butoxycarbonylmethylene)triphenylphosphorane

: 1384276-82-7
tert-butyl (Z)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

: 1345718-94-6
tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

Guidance literature:: In tetrahydrofuran; at -15 - 20 ℃; for 16h; optical yield given as %de;
DOI:10.1016/j.tetasy.2011.08.020

Reference yield:

: 1129-78-8
1-(3-bromopropoxy)-4-fluorobenzene

: 1384276-82-7
tert-butyl (Z)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

: 1345718-94-6
tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; sodium iodide / tetrahydrofuran / 16 h / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.67 h / -15 °C

3: tetrahydrofuran / 16 h / -15 - 20 °C

With potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium iodide; In tetrahydrofuran; 3: Wittig reaction;
DOI:10.1016/j.tetasy.2011.08.020

Reference yield:

: 401502-00-9
N-(3-(4-fluorophenoxy)propyl)prop-2-en-1-amine

: 1384276-82-7
tert-butyl (Z)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

: 1345718-94-6
tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.67 h / -15 °C

2: tetrahydrofuran / 16.33 h / -15 - 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran;
DOI:10.1016/j.tet.2011.12.084