(R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one

Base Information

Chemical Name:(R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one
CAS No.:1345718-97-9
Molecular Formula:C₃₀H₃₅FN₂O₃
Molecular Weight:490.618
Hs Code.:

Synonyms:(R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one

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Chemical Property of (R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one

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Technology Process of (R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one

There total 7 articles about (R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1345718-96-8
(R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-hydroxy-4-[N-benzyl-N-(α-methylbenzyl)amino]-piperidin-2-one

: 74-88-4
methyl iodide

: 1345718-97-9
(R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one

Guidance literature:: (R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-hydroxy-4-[N-benzyl-N-(α-methylbenzyl)amino]-piperidin-2-one; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.tetasy.2011.08.020

Reference yield:

: C₃₃H₄₃FN₂O₄

: 1345718-97-9
(R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzoic acid / toluene / 16 h / 80 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 16 h / 0 - 20 °C

With sodium hydride; benzoic acid; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetasy.2011.08.020

Reference yield:

: 1345718-94-6
tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

: 1345718-97-9
(R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 2 h / -78 °C

1.2: 12 h / -78 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 3 h / 35 °C

3.1: benzoic acid / toluene / 16 h / 80 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.2: 16 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; sodium hydride; benzoic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2011.08.020