(3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine

Base Information

Chemical Name:(3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine
CAS No.:1345718-98-0
Molecular Formula:C₃₀H₃₇FN₂O₂
Molecular Weight:476.634
Hs Code.:

Synonyms:(3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine

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Chemical Property of (3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine

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Technology Process of (3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine

There total 8 articles about (3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1345718-97-9
(R,R,R)-N(1)-[3'-(4''-fluorophenoxy)propyl]-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidin-2-one

: 1345718-98-0
(3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 60 ℃; for 16h;
DOI:10.1016/j.tetasy.2011.08.020

Reference yield:

: C₃₃H₄₃FN₂O₄

: 1345718-98-0
(3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: benzoic acid / toluene / 16 h / 80 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 16 h / 0 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 60 °C

With lithium aluminium tetrahydride; sodium hydride; benzoic acid; In tetrahydrofuran; toluene;
DOI:10.1016/j.tetasy.2011.08.020

Reference yield:

: 1345718-94-6
tert-butyl (E)-5-[N-allyl-N-3'-(4''-fluorophenoxy)propylamino]pent-2-enoate

: 1345718-98-0
(3S,4R,αR)-N(1)-(3'-(4''-fluorophenoxy)propyl)-3-methoxy-4-[N-benzyl-N-(α-methylbenzyl)amino]piperidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 2 h / -78 °C

1.2: 12 h / -78 - 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid / dichloromethane / 3 h / 35 °C

3.1: benzoic acid / toluene / 16 h / 80 °C

4.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

4.2: 16 h / 0 - 20 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 60 °C

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; sodium hydride; benzoic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.tetasy.2011.08.020