(S)-2-METHYLSUCCINIC ACID 1-METHYL ESTER

Base Information

• Chemical Name: (S)-2-METHYLSUCCINIC ACID 1-METHYL ESTER
• CAS No.: 111266-16-1
• Molecular Formula: C6H10 O4
• Molecular Weight: 146.143
• Hs Code.: 2918990090
• Mol file: 111266-16-1.mol

Synonyms:Butanedioicacid, methyl-, 1-methyl ester, (2S)- (9CI); Butanedioic acid, methyl-, 1-methylester, (S)-; l-Pyrotartaric acid, 1-methyl ester (6CI)

Chemical Property of (S)-2-METHYLSUCCINIC ACID 1-METHYL ESTER

Chemical Property:

• Boiling Point: 248.8±23.0 °C(Predicted)
• PKA: 4.44±0.19(Predicted)
• PSA: 63.60000
• Density: 1.159±0.06 g/cm3(Predicted)
• LogP: 0.27020

Purity/Quality:

99% ^*data from raw suppliers

(S)-4-Methoxy-3-methyl-4-oxobutanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-METHYLSUCCINIC ACID 1-METHYL ESTER

There total 8 articles about (S)-2-METHYLSUCCINIC ACID 1-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl itaconate (3377-31-9) → (R)-2-methylsuccinate-1-monomethyl ester (83509-04-0) + L-malic acid methyl ester (111266-16-1)

Guidance literature:

With hydrogen; triethylamine; Ru₂Cl₄((R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl)2; In tetrahydrofuran; toluene; at 35 ℃; for 24h; under 2206.5 Torr; Title compound not separated from byproducts; op = 79percent;

DOI:10.1016/S0040-4039(00)96006-4

Reference yield:

methyl itaconate (3377-31-9) → L-malic acid methyl ester (111266-16-1)

Guidance literature:

With hydrogen; [Rh(COD)(chiral phosphite ligand)2]BF₄; In ethyl acetate; at 20 ℃; for 12h; under 825.066 Torr;

DOI:10.1002/ejoc.200300222

Reference yield:

methanol (67-56-1) + 2-methylsuccinic anhydride (4100-80-5) → (R)-2-methylsuccinate-1-monomethyl ester (83509-04-0) + L-malic acid methyl ester (111266-16-1)

Guidance literature:

With modified cinchona alkaloid (DHQD)2AQN; In diethyl ether; at 25 ℃; for 4h; Title compound not separated from byproducts.;

DOI:10.1021/ja011766h

upstream raw materials:

methyl (S)-2-methylpent-4-enoate

2-methylsuccinic acid 1-methyl ester

propan-1-ol

methyl 2-methylsuccinate

Downstream raw materials:

(S,S)-2,5-dimethyl-adipic acid

(S)-dimethyl 2-methylsuccinate

(R,R)-2,5-dimethyl-adipic acid dimethyl ester