dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester

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Chemical Name:dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester
CAS No.:946125-91-3
Molecular Formula:C₂₀H₁₆F₂N₂O₆
Molecular Weight:418.354
Hs Code.:

Synonyms:dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester

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Chemical Property of dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester

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Technology Process of dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester

There total 4 articles about dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 946130-17-2
3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran

: 79-44-7
N,N-Dimethylcarbamoyl chloride

: 946125-91-3
dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester

Guidance literature:: 3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 61.0%

: 946125-91-3
dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.166667h; Inert atmosphere;

In N,N-dimethyl-formamide; mineral oil; at 20 ℃; Inert atmosphere;

Reference yield:

: 946125-65-1
1-(bromomethyl)-2-fluoro-3- nitrobenzene

: 946125-91-3
dimethylcarbamic acid 2-oxo-2H-3-(2-fluoro-3-nitrobenzyl)-4-methyl-6-fluoro-1-benzopyran-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 6 h / 0 - 20 °C / Inert atmosphere

2.1: sulfuric acid / 2 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 5 h / 20 °C / Inert atmosphere

With sulfuric acid; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; 2.1: |Pechmann Condensation;
DOI:10.1016/j.bmcl.2013.10.001