3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran

Base Information

Chemical Name:3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran
CAS No.:946130-17-2
Molecular Formula:C₁₇H₁₁F₂NO₅
Molecular Weight:347.275
Hs Code.:

Synonyms:3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran

Suppliers and Price of 3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran

There total 3 articles about 3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 946130-07-0
2-(2-fluoro-3-nitrobenzyl)-3-oxo-butyric acid ethyl ester

: 103068-41-3
4-fluororesorcinol

: 946130-17-2
3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran

Guidance literature:: With sulfuric acid; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2013.10.001

Reference yield:

: 946125-65-1
1-(bromomethyl)-2-fluoro-3- nitrobenzene

: 946130-17-2
3-(2-fluoro-3-nitrobenzyl)-7-hydroxy-4-methyl-6-fluoro-2-oxo-2H-1-benzopyran

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 6 h / 0 - 20 °C / Inert atmosphere

2.1: sulfuric acid / 2 h / 0 - 20 °C

With sulfuric acid; sodium hydride; In tetrahydrofuran; mineral oil; 2.1: |Pechmann Condensation;
DOI:10.1016/j.bmcl.2013.10.001